If you are renewing the ISE Admin certificate, then that node will restart its application services. While the application services are restarted, you should consider that node to be "out of service". That means if the node handles RADIUS requests for MAB/Profiling, then the switch/WLC will not get a response - and if you have another RADIUS server configured on the switch/WLC then that will be tried - and if it's online/reachable, then all is well.
If you are renewing the ISE EAP certificate, then there is no downtime on that node.